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Journal Article
Effect of Eradication of <i>Helicobacter pylori</i> on Expression Levels of FHIT, IL-8 and P73 in Gastric Mucosa of First-Degree Relatives of Gastric Cancer Patients
PLOS ONE
Objectives: Helicobacter pylori (H. pylori) infection plays an important role in the carcinogenesis and development of gastric cancer. Eradication of H. pylori can effectively reduce the risk of gastric cancer, but the underlying mechanisms are not f...
/Biology and life sciences/Anatomy/Biological tissue/Epithelium/Mucous membranes/Gastric mucosa/Biology and life sciences/Anatomy/Digestive system/Gastrointestinal tract/Gastric mucosa/Biology and life sciences/Genetics/Gene expression/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Bacterial pathogens/Helicobacter pylori/Biology and life sciences/Molecular biology/Molecular biology techniques/Molecular biology assays and analysis techniques/Gene expression and vector techniques/Protein expression
Difficult (11.5)
DOI: 10.1371/journal.pone.0124576
Journal Article
Host Responses in Life-History Traits and Tolerance to Virus Infection in <i>Arabidopsis thaliana</i>
PLoS Pathogens
Knowing how hosts respond to parasite infection is paramount in understanding the effects of parasites on host populations and hence host–parasite co-evolution. Modification of life-history traits in response to parasitism has received less attentio...
/Biology and life sciences/Developmental biology/Life cycles/Parasitic life cycles/Biology and life sciences/Ecology/Community ecology/Trophic interactions/Parasitism/Biology and life sciences/Organisms/Eukaryota/Plants/Brassica/Arabidopsis thaliana/Biology and life sciences/Organisms/Eukaryota/Plants/Flowering plants/Biology and life sciences/Parasitology/Parasitic life cycles
Very Difficult (16.5)
DOI: 10.1371/journal.ppat.1000124
Journal Article
The effect of a severe psychiatric illness on colorectal cancer treatment and survival: A population-based retrospective cohort study
PLOS ONE
Objectives: To identify inequalities in cancer survival rates for patients with a history of severe psychiatric illness (SPI) compared to those with no history of mental illness and explore differences in the provision of recommended cancer treatment...
/Medicine and health sciences/Diagnostic medicine/Cancer detection and diagnosis/Medicine and health sciences/Health care/Patients/Inpatients/Medicine and health sciences/Health care/Patients/Outpatients/Medicine and health sciences/Mental health and psychiatry/Mental health therapies/Medicine and health sciences/Oncology/Cancer detection and diagnosis
Very Difficult (16.7)
DOI: 10.1371/journal.pone.0235409
Journal Article
Species Invasion History Influences Community Evolution in a Tri-Trophic Food Web Model
PLoS ONE
Background: Recent experimental studies have demonstrated the importance of invasion history for evolutionary formation of community. However, only few theoretical studies on community evolution have focused on such views. Methodology and Principal F...
/Biology and life sciences/Conservation biology/Species extinction/Biology and life sciences/Ecology/Community ecology/Biology and life sciences/Ecology/Community ecology/Trophic interactions/Predation/Biology and life sciences/Evolutionary biology/Biology and life sciences/Evolutionary biology/Evolutionary immunology
Very Difficult (19.0)
DOI: 10.1371/journal.pone.0006731
Journal Article
Natural Selection on Female Life-History Traits in Relation to Socio-Economic Class in Pre-Industrial Human Populations
PLoS ONE
Life-history theory predicts that resource scarcity constrains individual optimal reproductive strategies and shapes the evolution of life-history traits. In species where the inherited structure of social class may lead to consistent resource diffe...
/Biology and life sciences/Evolutionary biology/Evolutionary processes/Natural selection/Biology and life sciences/Evolutionary biology/Evolutionary processes/Natural selection/Reproductive success/Biology and life sciences/Evolutionary biology/Population genetics/Genetic polymorphism/Biology and life sciences/Genetics/Phenotypes/Biology and life sciences/Genetics/Population genetics/Genetic polymorphism
Very Difficult (19.9)
DOI: 10.1371/journal.pone.0000606
Journal Article
Utility of an Algorithm to Increase the Accuracy of Medication History in an Obstetrical Setting
PLOS ONE
Background: In an obstetrical setting, inaccurate medication histories at hospital admission may result in failure to identify potentially harmful treatments for patients and/or their fetus(es). Methods: This prospective study was conducted to assess...
/Medicine and health sciences/Health care/Health care providers/Physicians/Medicine and health sciences/Pharmaceutics/Drug therapy/Medicine and health sciences/Pharmacology/Drugs/Medicine and health sciences/Pharmacology/Routes of administration/Medicine and health sciences/Women's health/Maternal health/Pregnancy
Very Difficult (22.3)
DOI: 10.1371/journal.pone.0151205
Journal Article
Does coronavirus disease 2019 history alone increase the risk of postoperative pulmonary complications after surgery? Prospective observational study using serology assessment
PLOS ONE
Background: Concern exists about the increasing risk of postoperative pulmonary complications in patients with a history of coronavirus disease 2019 (COVID-19). Objective: We conducted a prospective observational study that compared the incidence of ...
/Biology and life sciences/Biochemistry/Proteins/Immune system proteins/Antibodies/Biology and life sciences/Immunology/Immune system proteins/Antibodies/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Coronaviruses/SARS coronavirus/SARS CoV 2/Biology and life sciences/Organisms/Viruses/RNA viruses/Coronaviruses/SARS coronavirus/SARS CoV 2/Biology and life sciences/Organisms/Viruses/Viral pathogens/Coronaviruses/SARS coronavirus/SARS CoV 2
Very Difficult (17.7)
DOI: 10.1371/journal.pone.0300782
Journal Article
Estimating the prevalence alcohol use disorder and relapse risks in Kermanshah Province of Iran: Integrating direct, indirect methods, and tree-based analysis
PLOS One
Background: Alcohol Use Disorder (AUD) is a major health issue in various societies, particularly in Iran, with detrimental consequences. In this study, we examined the prevalence of AUD using direct and indirect methods (Network Scale-Up model (NUS)...
/Biology and life sciences/Nutrition/Diet/Alcohol consumption/Biology and life sciences/Psychology/Addiction/Alcoholism/Earth sciences/Geography/Human geography/Urban geography/Cities/Engineering and technology/Management engineering/Decision analysis/Decision trees/Medicine and health sciences/Epidemiology/Medical risk factors
Very Difficult (17.4)
DOI: 10.1371/journal.pone.0325107
Journal Article
Impact of COVID-19 on mucormycosis presentation and laboratory values: A comparative analysis
PLOS One
Background: The COVID-19 pandemic has led to an alarming increase in mucormycosis coinfections and its rapid progression. The overlapping risk factors and symptoms between COVID-19 and mucormycosis further complicate prompt detection, which is crucia...
/Biology and life sciences/Anatomy/Body fluids/Blood/Platelets/Biology and life sciences/Anatomy/Head/Face/Biology and life sciences/Cell biology/Cellular types/Animal cells/Blood cells/Platelets/Biology and life sciences/Physiology/Body fluids/Blood/Platelets/Medicine and health sciences/Anatomy/Body fluids/Blood/Platelets
Very Difficult (17.7)
DOI: 10.1371/journal.pone.0321897
Journal Article
Evolving life-history traits promote biodiversity via eco-evolutionary feedback mechanisms
PLOS Biology
To what extent is biodiversity shaped by environmental conditions, and to what extent is it the result of self-organization? Both natural processes and organismal properties may contribute to promoting diversity. Here, we show that one such process,...
/Biology and life sciences/Ecology/Biodiversity/Biology and life sciences/Ecology/Ecological metrics/Species diversity/Biology and life sciences/Ecology/Ecological niches/Biology and life sciences/Evolutionary biology/Evolutionary processes/Evolutionary adaptation/Biology and life sciences/Evolutionary biology/Evolutionary processes/Natural selection
Very Difficult (16.8)
DOI: 10.1371/journal.pbio.3003492
Journal Article
Associations between cancer history, social distancing behaviors, and loneliness in adults during the COVID-19 pandemic
PLOS ONE
Background: During the COVID-19 pandemic, enforced social distancing initiatives have highlighted differences in social distancing practices and the resulting loneliness in various populations. The objective of this study was to examine how cancer hi...
/Medicine and health sciences/Epidemiology/Pandemics/Medicine and health sciences/Medical conditions/Infectious diseases/Infectious disease control/Social distancing/Medicine and health sciences/Medical conditions/Infectious diseases/Viral diseases/COVID 19/Medicine and health sciences/Mental health and psychiatry/Medicine and health sciences/Oncology/Cancers and neoplasms
Very Difficult (16.4)
DOI: 10.1371/journal.pone.0281713
Journal Article
An Epidemiological Reappraisal of the Familial Aggregation of Prostate Cancer: A Meta-Analysis
PLoS ONE
Studies on familial aggregation of cancer may suggest an overall contribution of inherited genes or a shared environment in the development of malignant disease. We performed a meta-analysis on familial clustering of prostate cancer. Out of ...
/Medicine and health sciences/Epidemiology/Cancer epidemiology/Medicine and health sciences/Epidemiology/Medical risk factors/Cancer risk factors/Medicine and health sciences/Oncology/Cancer risk factors/Medicine and health sciences/Oncology/Cancers and neoplasms/Genitourinary tract tumors/Prostate cancer/Medicine and health sciences/Urology/Prostate diseases/Prostate cancer
Very Difficult (17.3)
DOI: 10.1371/journal.pone.0027130
Journal Article
Impact of prior cancer history on the prognosis of extranodal NK/T-cell lymphoma
PLOS ONE
Our goal was to assess the impact of prior cancer history on the prognosis of extranodal NK/T-cell lymphoma (ENKTCL). We searched the SEER database to retrospectively enroll patients with ENKTCL. The effects of cancer history on overall survival (OS...
/Medicine and health sciences/Clinical medicine/Clinical oncology/Radiation therapy/Medicine and health sciences/Dermatology/Skin neoplasms/Skin tumors/Medicine and health sciences/Hematology/Hematologic cancers and related disorders/Medicine and health sciences/Oncology/Cancer treatment/Medicine and health sciences/Oncology/Cancer treatment/Radiation therapy
Difficult (11.0)
DOI: 10.1371/journal.pone.0311094
Journal Article
The Conservation and Management of Tunas and Their Relatives: Setting Life History Research Priorities
PLoS ONE
Scombrids (tunas, bonitos, Spanish mackerels and mackerels) support important fisheries in tropical, subtropical and temperate waters around the world, being one of the most economically- and socially-important marine species globally. Their sustain...
/Biology and life sciences/Agriculture/Aquaculture/Fisheries/Biology and life sciences/Developmental biology/Modes of reproduction/Sexual reproduction/Spawning/Biology and life sciences/Marine biology/Marine fish/Biology and life sciences/Organisms/Eukaryota/Animals/Vertebrates/Fish/Marine fish/Biology and life sciences/Organisms/Eukaryota/Animals/Vertebrates/Fish/Osteichthyes/Tuna
Very Difficult (22.9)
DOI: 10.1371/journal.pone.0070405
Journal Article
Combining biomarker and virus phylogenetic models improves HIV-1 epidemiological source identification
PLOS Computational Biology
To identify and stop active HIV transmission chains new epidemiological techniques are needed. Here, we describe the development of a multi-biomarker augmentation to phylogenetic inference of the underlying transmission history in a local population...
/Biology and life sciences/Biochemistry/Biomarkers/Biology and life sciences/Evolutionary biology/Evolutionary systematics/Phylogenetics/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Immunodeficiency viruses/HIV/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Immunodeficiency viruses/HIV/HIV-1/Biology and life sciences/Microbiology/Medical microbiology/Microbial pathogens/Viral pathogens/Retroviruses/Lentivirus/HIV
Very Difficult (14.4)
DOI: 10.1371/journal.pcbi.1009741
Journal Article
The association between environmental factors and the development of Crohn’s disease with focusing on passive smoking: A multicenter case-control study in Japan
PLOS ONE
Background: The number of patients with Crohn’s disease (CD) in Japan has recently been increasing. We examined the association between environmental factors and the development of CD in Japanese focusing on passive smoking. Methods: We conducted a m...
/Biology and life sciences/Immunology/Clinical immunology/Autoimmune diseases/Crohn's disease/Biology and life sciences/Nutrition/Diet/Alcohol consumption/Biology and life sciences/Psychology/Behavior/Habits/Smoking habits/Medicine and health sciences/Clinical medicine/Clinical immunology/Autoimmune diseases/Crohn's disease/Medicine and health sciences/Diagnostic medicine
Very Difficult (14.1)
DOI: 10.1371/journal.pone.0216429
Journal Article
Improved Learning in U.S. History and Decision Competence with Decision-Focused Curriculum
Decision making is rarely taught in high school, even though improved decision skills could benefit young people facing life-shaping decisions. While decision competence has been shown to correlate with better life outcomes, few intervention...
/Biology and life sciences/Neuroscience/Cognitive science/Cognition/Decision making/Biology and life sciences/Neuroscience/Cognitive science/Cognitive psychology/Academic skills/Biology and life sciences/Neuroscience/Cognitive science/Cognitive psychology/Decision making/Biology and life sciences/Neuroscience/Cognitive science/Cognitive psychology/Learning/Human learning/Biology and life sciences/Neuroscience/Learning and memory/Learning/Human learning
Very Difficult (14.5)
DOI: 10.1371/journal.pone.0045775
Journal Article
Patient journey through cases of depression from claims database using machine learning algorithms
PLOS ONE
Health insurance and acute hospital-based claims have recently become available as real-world data after marketing in Japan and, thus, classification and prediction using the machine learning approach can be applied to them. However, the methodology...
/Biology and life sciences/Immunology/Clinical immunology/Allergies/Allergic diseases/Allergic rhinitis/Biology and life sciences/Physiology/Physiological processes/Sleep/Computer and information sciences/Artificial intelligence/Machine learning/Medicine and health sciences/Clinical medicine/Clinical immunology/Allergies/Allergic diseases/Allergic rhinitis/Medicine and health sciences/Gastroenterology and hepatology/Gastritis
Very Difficult (16.9)
DOI: 10.1371/journal.pone.0247059
Journal Article
Inferring Population Size History from Large Samples of Genome-Wide Molecular Data - An Approximate Bayesian Computation Approach
PLOS Genetics
Inferring the ancestral dynamics of effective population size is a long-standing question in population genetics, which can now be tackled much more accurately thanks to the massive genomic data available in many species. Several promising methods t...
/Biology and life sciences/Computational biology/Genomics statistics/Biology and life sciences/Evolutionary biology/Population genetics/Biology and life sciences/Evolutionary biology/Population genetics/Effective population size/Biology and life sciences/Genetics/Genomics/Biology and life sciences/Genetics/Genomics/Genomics statistics
Difficult (13.7)
DOI: 10.1371/journal.pgen.1005877
Journal Article
Incarceration history and ethnic bias in hiring perceptions: An experimental test of intersectional bias & psychological mechanisms
PLOS ONE
This study seeks to better understand mechanisms of bias against formerly incarcerated and ethnically minoritized job applicants as well as the interactive effects of those two identities. In a sample of 358 hiring managers in the United States, the...
/Biology and life sciences/Psychology/Behavior/Recreation/Sports/Biology and life sciences/Psychology/Psychological attitudes/Biology and life sciences/Sports science/Sports/Medicine and health sciences/Pharmacology/Drug interactions/People and places/Population groupings/Ethnicities
Very Difficult (23.7)
DOI: 10.1371/journal.pone.0280397